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Navigating bustling city streets can be a challenge for anyone at times. Can you imagine crossing a busy street, walking up a flight of stairs or using public transportation without the gift of sight? In this Science in the City you'll catch a glimpse of how Guide Dogs for the Blind envisions a world with greater inclusion, opportunity, and independence by optimizing the unique capabilities of people and dogs. Exploratorium biologist Karen Kalumuck will examine how increasing temperatures affect specific organisms at the polesfrom phytoplankton to polar bears! Dr. Francis Collins is the Director of the National Human Genome Research Institute, which is responsible for coordinating the government-sponsored effort to map and sequence the entire human genome, considered by many as one of the most important scientific undertakings of our time. Dr. Collins is a physician and geneticist whose own work led to the identification of the genes for cystic fibrosis, neurofibromatosis, and Huntington's disease. In this Webcast, Dr. Collins explains the different strategies for finding disease genes, the competition between public and private efforts to decode the human genome, and the next steps for the Human Genome Project, now that the first accurate gene maps have been created.