The practice of medicine today is different from the practice of medicine twenty years ago—and the practice of medicine twenty years from now will be even more dramatically different. This discussion with Leroy Hood, President of the Institute for Systems Biology, and Dr. Deepak Srivastava, Younger Family Director of the Gladstone Institute of Cardiovascular Disease, engages with questions of how technology and the study of the genome will shape the future of medicine and provide the opportunity for increasingly patient-specific treatments.