• Visit
    • Buy Tickets
    • Calendar
    • After Dark Thursdays
    • Exhibits
    • Artworks on View
    • Getting Here
    • Event Rentals
  • Education
    • Professional Development Programs
    • Tools for Teaching and Learning
    • Learning About Learning
    • Community Programs
    • Educator Newsletter
  • Explore
    • Browse by Subject
    • Activities
    • Video
    • Exhibits
    • Apps
    • Blogs
    • Websites
  • About Us
    • Our Story
    • Partnerships
    • Global Collaborations
    • Explore Our Reach
    • Arts at the Exploratorium
    • Contact Us
  • Join + Support
    • Donate today!
    • Membership
    • Join our donor community
    • Engage your business
    • Attend a fundraiser
    • Explore our reach
    • Thank you to our supporters
    • Host your event
    • Volunteer
  • Store
  • Visit
    • Buy Tickets
    • Frequently Asked Questions
    • Calendar
      • Today
      • This Week
      • After Dark Thursday Nights
      • Arts
      • Conferences
      • Cinema Arts
      • Free and Community Events
      • Fundraising Events
      • Kids + Families
      • Live Webcasts
      • Members
      • Ongoing + Series
      • Special Hours and Open Mondays
      • Private Event Closures
    • Hours
    • Getting Here
    • Museum Map
    • Reduced Rates & Community Day
    • Accessibility
    • Tips for Visiting with Kids
    • How to Exploratorium
    • Exhibits
    • Tactile Dome
    • Artworks on View
    • Cinema Arts
    • Kanbar Forum
    • Black Box
    • Museum Galleries
      • Bernard and Barbro Osher Gallery 1: Human Phenomena
        • Exhibition: Science of Sharing
          • Educator Activities
        • Tactile Dome
          • 1971 Press Release
        • Black Box
        • Curator Statement
      • Gallery 2: Tinkering
        • Curator Statement
      • Bechtel Gallery 3: Seeing and Listening
        • Curator Statement
      • Gallery 4: Living Systems
        • Curator Statement
      • Gallery 5: Outdoor Exhibits
        • Curator Statement
      • Fisher Bay Observatory Gallery 6: Observing Landscapes
        • Wired Pier Environmental Field Station
        • Curator Statement
      • PlayLists
        • All PlayLists
        • A Different Light
        • “We” or “Just Me”?
        • See Yourself in Cells
        • Greatest Hits: Gallery 2
        • Greatest Hits: Gallery 3
        • Greatest Hits: Gallery 4
        • Museum Map
    • Restaurant & Café
    • School Field Trips
      • Getting Here
        • Bus Routes for Field Trips and Other Groups
      • Prices and Discounts
      • Planning Guide
      • Reservations
        • Field Trip Request Form
      • Resources
    • Groups / Tour Operators
      • Group Visit Request Form
    • Event Rentals
      • COVID-Compliant Options
      • Full Facility & Gallery Bundles
      • Fisher Bay Observatory Gallery & Terrace
      • East Gallery
      • Bechtel Central Gallery
      • Osher West Gallery
      • Kanbar Forum
      • Weddings
      • Proms and School Events
      • Daytime Meeting & Event Options
      • Happy Hour on the Water
      • Rentals FAQ
      • Event Planning Resources
      • Rental Request Form
      • Download Brochure (pdf)
    • Exploratorium Store
    • Contact Us
    • Español
    • 繁體中文
    • 简体中文
    • 한국어
    • Français
    • Deutsch
    • Português
    • 日本語
  • Education
    • Professional Development Programs
      • Teacher Institute
        • About the Teacher Institute
        • Summer Institute for Teachers
        • Teacher Induction Program
        • Leadership Program
        • Teacher Institute Research
        • CA NGSS STEM Conferences
          • NGSS STEM Conference 2020
        • Science Snacks
          • Browse by Subject
          • Special Collections
          • Science Snacks A-Z
          • NGSS Planning Tools
          • Frequently Asked Questions
        • Digital Teaching Boxes
        • Meet the Teacher Institute Staff
        • Resources for Supporting Science Teachers
      • Institute for Inquiry
        • What Is Inquiry?
        • Inquiry-based Science and English Language Development
          • Educators Guide
            • Conceptual Overview
              • Science Talk
              • Science Writing
            • Classroom Video Gallery
              • Magnet Investigation
              • Snail Investigation
            • Teacher Professional Development
            • Project Studies
            • Acknowledgments
          • Conference: Exploring Science and English Language Development
            • Interviews with Participants
            • Plenary Sessions
            • Synthesis, Documentation, and Resources
        • Workshops
          • Participant Portal
          • Fundamentals of Inquiry
            • Summary Schedule
          • BaySci Science Champions Academy
          • Facilitators Guides
          • Commissioned Workshops
        • Resource Library
        • Meet the IFI Staff
      • Resources for California Educators
      • K-12 Science Leader Network
      • Resources for Supporting Science Teachers
      • Field Trip Explainer Program
    • Tools for Teaching and Learning
      • Learning Toolbox
      • Science Snacks
      • Digital Teaching Boxes
      • Science Activities
      • Tinkering Projects
      • Videos
      • Exhibits
      • Publications
      • Apps
      • Educator Newsletter
      • Exploratorium Websites
    • Educator Newsletter
    • Advancing Ideas about Learning
      • Visitor Research and Evaluation
        • What we do
        • Reports & Publications
        • Projects
        • Who we are
      • Center for Informal Learning in Schools
    • Community Programs
      • High School Explainer Program
      • Xtech
      • Community Educational Engagement
      • California Tinkering Afterschool Network
        • About
        • Partners
        • Resources
        • News & Updates
        • Further Reading
  • Explore
    • Browse by Subject
      • Arts
      • Astronomy & Space Sciences
        • Planetary Science
        • Space Exploration
      • Biology
        • Anatomy & Physiology
        • Ecology
        • Evolution
        • Genetics
        • Molecular & Cellular Biology
        • Neuroscience
      • Chemistry
        • Combining Matter
        • Food & Cooking
        • Materials & Matter
        • States of Matter
      • Data
        • Data Collection & Analysis
        • Modeling & Simulations
        • Visualization
      • Earth Science
        • Atmosphere
        • Geology
        • Oceans & Water
      • Engineering & Technology
        • Design & Tinkering
        • Real-World Problems & Solutions
      • Environmental Science
        • Global Systems & Cycles
        • Human Impacts
      • History
      • Mathematics
      • Nature of Science
        • Measurement
        • Science as a Process
        • Size & Scale
        • Time
      • Perception
        • Light, Color & Seeing
        • Listening & Hearing
        • Optical Illusions
        • Scent, Smell & Taste
        • Tactile & Touch
      • Physics
        • Electricity & Magnetism
        • Energy
        • Heat & Temperature
        • Light
        • Mechanics
        • Quantum
        • Sound
        • Waves
      • Social Science
        • Culture
        • Language
        • Psychology
        • Sociology
    • Browse by Content Type
      • Activities
      • Blogs
      • Exhibits
      • Video
      • Websites
      • Apps
        • Total Solar Eclipse
  • About Us
    • Contact Info
    • Our Story
    • Our History
      • 50 Years 1969–2019
    • Fact Sheet
    • Impact Report
    • Awards
    • Arts at the Exploratorium
      • Artworks on View
      • Artist-in-Residence Program
      • Cinema Arts
        • History and Collection
        • Cinema Artists-in-Residence
        • Resources and Collaborating Organizations
        • Kanbar Forum
      • Center for Art & Inquiry
        • Begin Here
          • Lessons
            • Bob Miller/Light Walk
            • Ruth Asawa/Milk Carton Sculpture
          • Workshops
      • Resonance
        • About the Series
        • See & Hear
        • Past Seasons
      • Over the Water
      • Black Box
      • Upcoming Events
      • Temporary Exhibitions
      • Arts Program Staff
      • Arts Committee and Advisers
    • Newsletter
    • Educator Newsletter
    • Press Office
    • Senior Leadership
    • Board of Trustees
    • Board of Trustees Alumni
    • Staff Scientists
    • Staff Artists
    • Partnerships
      • Building Global Connections
        • Global Collaborations
          • Projects
          • Approach
          • People
          • Impact
      • Partnering with Science Agencies
        • NASA
        • NOAA
      • Partnering with Educational Institutions
      • Osher Fellows
    • Exhibit Making
    • Institute for Inquiry
    • Teacher Institute
    • Online Engagement
    • Explainer Programs
    • Studio for Public Spaces
    • Job Opportunities
    • Become a Volunteer
    • Follow & Share
    • FY20 Audit Report
    • 990 FY19 Tax Return
    • Use Policy
      • Privacy Policy
      • Intellectual Property Policy
  • Join + Support
    • Donate today!
    • Membership
      • Membership FAQ
      • Member Benefits
      • After Dark Membership
      • Member Events
      • May Is for Members
    • Join our donor community
    • Engage your business
      • Corporate Membership
      • Luminary Partnerships
    • Attend a fundraiser
      • Wonder Funday
      • Science of Cocktails
      • Party at the Piers
        • Event Leadership and Host Committee
    • Explore our reach
    • Thank you to our supporters
    • Volunteer
      • Benefits
      • How to Apply
      • Application for Corporate Groups
      • Application for Internships
      • Application for Professional Societies
      • Application for School Groups & Clubs
      • Our Contract
      • Application for Individuals
      • Opportunities
  • Press Office
    • Press Releases
    • News Coverage
    • Events Calendar
    • Fact Sheet
    • Photographs
    • Press Video
    • Press Kits
    • Press Visits
    • Exploratorium Logos
    • Recent Awards
    • Praise for the Exploratorium
    • Join Our Press List
  • Store
 

Learn with us online while the Exploratorium is temporarily closed. You can help us reopen—donate today.

Exploratorium
Exploratorium
  • Visit
    • Buy Tickets
    • Calendar
    • After Dark Thursdays
    • Exhibits
    • Artworks on View
    • Getting Here
    • Event Rentals
  • Education
    • Professional Development Programs
    • Tools for Teaching and Learning
    • Learning About Learning
    • Community Programs
    • Educator Newsletter
  • Explore
    • Browse by Subject
    • Activities
    • Video
    • Exhibits
    • Apps
    • Blogs
    • Websites
  • About Us
    • Our Story
    • Partnerships
    • Global Collaborations
    • Explore Our Reach
    • Arts at the Exploratorium
    • Contact Us
  • Join + Support
    • Donate today!
    • Membership
    • Join our donor community
    • Engage your business
    • Attend a fundraiser
    • Explore our reach
    • Thank you to our supporters
    • Host your event
    • Volunteer
  • Store
Science Snacks
Science activity that models the structure of a virus

Viral Packaging

Get the most bang for your genomic buck.

Solve the problem that took viruses millions of years to conquer by efficiently fitting nucleic acid and proteins into a small package.

COVID-19 Learning Note: Without complete cellular machinery, coronaviruses cannot reproduce on their own. Unlike bacteria, which can multiply inside or outside your body, a virus has to infect a living cell to make more viruses. This means any coronaviruses that happen to get on a surface will inactivate over time and that the most likely way to get infected is through direct contact with an infected person.


Grade Bands: 
6-8
9-12
Subject: 
Biology
Molecular & Cellular Biology
Genetics
Mathematics
Nature of Science
Science as a Process
Keywords: 
virus
model
patterns
nature
microorganism
covid-19
NGSS and EP&Cs: 
LS
LS1
LS3
LS4
CCCs
Patterns
Scale, Proportion, and Quantity
Structure and Function

  • Facebook logo
  • Reddit logo
  • Twitter logo


Tools and Materials

For each model, you'll need:

  • Card stock or other heavy paper
  • Two to three feet (60–90 centimeters) of yarn
  • Six extra-large cotton balls
  • Scissors
  • Tape
  • Printable triangle template provided in the Assembly section below (contains two strips, each with 20 equilateral triangles whose sides are 1.5 inches [3.8 cm] long)
  • Optional: small, plastic zip-top bag (not shown)

Assembly

Print or copy the triangle template onto the cardstock (the two strips of 20 triangles each should fit onto one standard 8.5 x 11-inch [A4] sheet). Only one strip is required for each model.


To Do and Notice

Cut out the individual equilateral triangles from the template. Experiment with different ways of taping up to 20 of the triangles together so that they completely enclose the yarn and cotton balls.


What’s Going On?

Viruses are composed of nucleic acid genomes and interior proteins that are surrounded by a protective protein shell called a capsid.

Instead of making the capsid out of one giant protein, viruses typically utilize many identical copies of the same protein that combine together to form this outer shell. This way, the virus can be economical, using one gene repetitively to make many small proteins instead of devoting a large portion of its genome to making a large protein coat.  

When making your paper container, you may have found a shape that uses several triangles to enclose the yarn and cotton balls, which represent a virus's nucleic acid and interior proteins, respectively. The majority of viruses are composed of triangular protein sub-units that associate to form an icosahedron—a 20-sided shape. This shape helps the virus to minimize its surface-area-to-volume ratio, which allows it to carry the most genetic material and internal proteins inside a given protein shell.

One way to categorize viruses is by whether or not they are surrounded by a membrane, called a viral envelope. A large number of viruses that infect humans have envelopes, including HIV, the virus that causes AIDS. You can place your capsid into the plastic bag to model these enveloped viruses.

Coronaviruses, such as the one that causes COVID-19, also have envelopes. Unlike HIV, they have helical interiors, which is another common shape for viruses.


Going Further

Icosahedrons have three axes of rotational symmetry—two-fold (180°), three-fold (120°) and five-fold (72°). At the two-fold axis of symmetry, the shape will look the same if it’s rotated on this axis 180°. Can you find all three axes of symmetry?

This model can also be used to illustrate the concept of gene therapy. Gene therapy seeks to treat diseases caused by defective or deficient proteins by introducing genetic material as medicine. Instead of manufacturing and injecting a functional version of the protein, gene therapists modify viruses so that their genomes contain a copy of the gene that encodes for the correct form of the diseased protein. Viral genes are removed from the genome, so that when the virus—now a viral vector—enters the target cell, it produces correct copies of the therapeutic protein instead of creating new virions (complete virus particles).

Gene therapy has been used in clinical trials to treat a wide range of diseases, including HIV, hemophilia, cancer, and “bubble-boy disease” (Severe Combined Immune Deficiency).

If you are a teacher making these models with your class, we recommend one model for every 1–2 students.



Science activity that investigates deodorant's effects on skin bacteria
Salty Pits

Explore how different deodorants affect the bacteria in your armpit.

Science activity that explores the size and scale of microscopic biology
Life Size

Explore the size and scale of microscopic biology.

Science activity that explores how yogurt is made
Bacteria Culture Club

Make yogurt from yogurt.


Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Attribution: Exploratorium Teacher Institute

  • Education
    • Teacher Institute
    • Tools for Teaching and Learning
      • Science Snacks
        • Browse by Subject
        • Special Collections
        • Science Snacks A-Z
        • NGSS Planning Tools
        • Frequently Asked Questions

Connect with us!

  •   Sign up for our educator newsletter
  •   Follow #ExploEDU
  •   Teacher Institute YouTube
  •   Teacher Institute Facebook
  •  teacherinstitute @exploratorium.edu
Exploratorium
Visit
Join
Give

Pier 15
(Embarcadero at Green Street)
San Francisco, CA 94111
(415) 528-4444

Contact Us

  • Plan Your Visit
  • Buy Tickets
  • Hours
  • Getting Here
  • Calendar
  • Tactile Dome
  • Store
  • About Us
  • Become a Member
  • Donate
  • Event Rentals
  • Jobs
  • Volunteer
  • Press Office

Get at-home activities and learning tools delivered straight to your inbox

© 2020 Exploratorium | Terms of Service | Privacy Policy | Your California Privacy Rights |